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PAS 1
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"Diarrhea, dyspnea, tympany, arching of the back, loss of condition, and loss of hair from the back were the prominent signs when Aristolochia bracteata was given orally to goats. The main lesions were haemorrhages in the lungs, heart, and kidneys, fatty change and congestion in the liver, mucoid abomasitis and enteritis and straw-colored fluid in serous cavities. An increase in aspartate aminotransferase activity, ammonia and urea concentrations and a decrease in the concentrations of total protein and magnesium were detected in the serum." [Barakat, Seif eldawla & Wasfi, Ibrahim & Adam, S.. (1983). The Toxicity of Aristolochia bracteata in Goats. Veterinary pathology. 20. 611-6. 10.1177/030098588302000513.]https://www.researchgate.net/publication/16558798_The_Toxicity_of_Aristolochia_bracteata_in_Goats
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PAS 2
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"The acute toxic effects of aristolochic acid (AA) were tested in rats and mice of both sexes. Oral or intravenous administration in high doses was followed by death from acute renal failure within 15 days. Histologically, the predominant features were severe necrosis affecting the renal tubules, atrophy of the lymphatic organs and large areas of superficial ulceration in the forestomach, followed by hyperplasia and hyperkeratosis of the squamous epithelium. The LD50 ranged from 56 to 203 mg/kg orally or 38 to 83 mg/kg intravenously, depending on species and sex." [Mengs, U. Acute toxicity of aristolochic acid in rodents. Arch Toxicol 59, 328–331 (1987). https://doi.org/10.1007/BF00295084] https://link.springer.com/article/10.1007/BF00295084#citeas
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PAS 3
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"The present study is aimed at determining the hepatoprotective effect of aqueous extract of Aristolochia bracteolata leaves in paracetamol induced liver injury model in rats by administrating paracetamol on the 4th day @2g/kg b.wt. orally. Group III and IV rats were pretreated with A. bracteolata leaf extract @200mg/kg b.wt and Silymarin @200mg/kg b.wt, orally once daily for the rst 3 days respectively. After the experimental period liver tissues were collected and subjected to histopathological analysis. The histopathological studies showed marked restoration of cellular abnormalities." [Moharana, Baisakhi & Pavithra, S. & Palaninathan, Preetha & Balachandran, C. & Thangapandiyan, M. & Acharya, P. & Choudhury, Subhagata. (2017). Effect of aqueous extract of aristolochia bracteolata leaves on paracetamol induced liver toxicity in rats. Indian Veterinary Journal. 94. 70-71.] https://www.researchgate.net/publication/322752151_Effect_of_aqueous_extract_of_aristolochia_bracteolata_leaves_on_paracetamol_induced_liver_toxicity_in_rats
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Agro Ecological Zone
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Agro Ecological Sub Region (ICAR) Madhya Bharat plateau Western Malwa plateau, Eastern Gujarat plain, Vindhyan and Satpura range and Narmada Valley hot, moist semi-arid eco-subregion (5.2), Agro-Climatic Region (Planning Commission) Gujarat Plains and Hills Region (XIII), Agro Climatic Zone (NARP) Middle Gujarat Agro Climatic Zone (GJ-3)
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Practice ID
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DTP0010000002761
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Annotation ID
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GIAN/GAVL/355
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Reference
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Lok(3)5, Oct-1998, Pg.No.-8
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Pest Group
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Rodentia
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Pest Scientific Names
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(Rattus rattus)
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Technology Transfer Terms
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DIY
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