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PAS 1
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Calotropis gigantea. The literature survey shows that a limed work has been reported in the latex part. This milkweed (arka) shows a numerous biological activities. Still there is very few mechanistic pharmacological investigation works were documented. In this review, the percentage of the research work in respect to different plant parts was documented. This informative article also emphasize the absence of pharmacological activity study on plant parts like stem bark, flower twig etc. Henceforth, this review article may play a significant role in near future to explore the novel therapeutic phytoconstituents.[ Prativa Biswasroy, Sthitapragnya Panda, Debajyoti Das, Durga Madhab Kar, Goutam Ghosh. Pharmacological investigation of Calotropis gigantea: A benevolent herb of Nature. Research J. Pharm. and Tech. 2020; 13(1): 461-467. doi: 10.5958/0974-360X.2020.00090.6] https://rjptonline.org/HTMLPaper.aspx?Journal=Research%20Journal%20of%20Pharmacy%20and%20Technology;PID=2020-13-1-90
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PAS 2
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Calotropis gigantea and Calotropis procera are small shrub, which are used conventionally to treat many diseases such as cancer, diabetes and intestinal disease in African and Asian countries. There have been always an increased focus on primary health care: basic health care which is effective and affordable by developing countries.[ Shripad M. Bairagi, Prashant Ghuze, Ritu Gilhotra, harmacology of Natural Products: An recent approach on Calotropis gigantea and Calotropis procera, Ars Pharm. 2018; 59(1): 37-44], http://scielo.isciii.es/pdf/ars/v59n1/2340-9894-ars-59-1-37.pdf
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PAS 3
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Aak (Calotropis procera) is a drug of herbal origin, which has been in use for medicinal purpose since time immemorial. Aak was first described by Abu Hanifa (circa 270 A.H) in his book of plants. According to Burhan, Usher is a Persian name for all plants having a milky juice and specially plants known in India as Aak. It is found more or less throughout India, in warm and dry places. It is a native of China and Malaysia and distributed in many countries all over world. IT has Mohallil (Resolvent), Akkal (Corrosive), Jali (Detergent), Mus’hil (Purgative), Munaffis-e-Balgham (Expectorant) and Musakkin (Analgesic) etc. properties. Pharmacological studies have revealed that the drug has effectively been employed for the treatment of various ailments like Waja-Ul-Mufasil (arthritis), Istisqa (ascites), Iltehab (inflammatory conditions), Juzam (leprosy) and Zeeq-Un-Nafs (asthma) etc. In this paper, an effort has been made to compile the actions and therapeutic uses of Aak (Calotropis procera). [Shamim, Saad Ahmed and Lubna Fatima,Pharmacological actions and therapeutic uses of Aak (Calotropis procera): A Review, The Pharma Innovation Journal 2019; 8(2): 40-47] http://www.thepharmajournal.com/archives/2019/vol8issue2/PartA/7-12-81-393.pdf
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PAS 4
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Calotropis gigantea R. Br. (Asclepiadaceae) a wildly growing plant has been reported to possess number of medicinal properties and other purposes. The purpose of the present study was to evaluate scientifically the anti-diarrheal effects of C. gigantea used traditionally in Indian system of medicine using castor oil-induced diarrhoea model. The anti-diarrheal effect of hydroalcoholic (50:50) extract of aerial part of Calotropis gigantea was studied against castor oil-induced-diarrhea model in rats. The gastrointestinal transit rate was expressed as the percentage of the longest distance traversed by the charcoal divided by the total length of the small intestine. The weight and volume of intestinal content induced by castor oil were studied by enteropooling method. Like atropine (3 mg/kg, i.p.) there were significant reductions in fecal out put and frequency of droppings when the plant extracts of 200 and 400 mg/kg doses were administered intraperitoneally compared with castor oil treated rats. All doses of the plant extracts also significantly retarded the castor-oil induced enteropooling and intestinal transit. The dose 100 (P<0.01), 200 and 400 mg/kg significantly inhibited (P<0.001) weight and volume of intestinal content. The remarkable anti-diarrheal effect of C.gigantea extract against castor oil-induced diarrhea model attests to its utility in a wide range of diarrheal states [Chitme, Havagiray R & Chandra, Mehrdad & Kaushik, Sadhna. (2004). Studies on anti-diarrheal activity of Calotropis gigantea R. BR. in experimental animals. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques. 7. 70-5.] https://www.researchgate.net/publication/8560793_Studies_on_anti-diarrheal_activity_of_Calotropis_gigantea_R_BR_in_experimental_animals/citation/download
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PAS 5
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Calotropis gigantea (Asclepiadaceae) is a perennial herb with a long history of use in traditional medicines. A wide range of chemical compounds including cardiac glycosides, flavonoids, terpenoids, alkaloids, tannins, & resins has been isolated from this plant. The plant has been used for various disease condition including leprosy, ulcers, tumors and piles. Various pharmacological activities reported like analgesic activity, antipyretic activity, pregnancy interceptive activity, CNS activity, anti-inflammatory activity, procoagulant activity, anti-diarrhoeal activity, free radical scavenging activity, antimicrobial activity, anti-tumor activity, antifungal activity, antitussive activity, and antifeedant activity.[ Singh N, Gupta P, Patel AV and Pathak AK: Calotropis gigantea: a review on its phytochemical & pharmacological profile. Int J Pharmacognosy 2014; 1(1): 1-8. doi:10.13040/IJPSR.0975-8232.1(1).1-8.] https://ijpjournal.com/bft-article/calotropis-gigantea-a-review-on-its-phytochemical-pharmacological-profile/?view=fulltext
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Agro Ecological Zone
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Agro Ecological Sub Region (ICAR) Central Highlands (Malwa), Gujarat Plain (5.1) , Agro-Climatic Zone (Planning Commission) Gujarat Plains and hills region (XIII), Agro Climatic Zone (NARP) North Saurashtra, South Saurashtra (GJ-6,GJ-7)
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Community Practices
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Rice grains are cooked along with black gram, black salts and black pepper. The recipe so prepared is given once or twice in a day for one month to enhance lactation in cattle.[ Raj KumarVerma. An ethnobotanical study of plants used for the treatment of livestock diseases in Tikamgarh District of Bundelkhand, Central India, Asian Pacific Journal of Tropical Biomedicine Volume 4, Supplement 1, May 2014, Pages S460-S467], Accessed at https://www.sciencedirect.com/science/article/pii/S2221169115303117 on August 9, 2020.
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Practice ID
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DTP0010000000671
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Annotation ID
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GIAN/GAVL/1788
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Reference
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HBN database
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Disease
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Retention of Foetal membrane / Placenta (ROFM/ROP)
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Disease Description
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Third phase of parturition in Cattle is voiding foetal membrane or placenta, when animal fails to do so for more the 24 hours of time after parturition, it is indicated as Retention of placenta. If complicated, can cause, post-partum metritis, low milk yield, poor reproductive performance etc.
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Management Practices
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“A typical, easy and effective protocol for retained placenta in cows is proved 80% effective and thus recommended for practice.” 1 U Umadevi, 2 P Madhu Mathi, 3 T Umakanthan Ethno-veterinary remedy for placental retention in cows Volume 3; Issue 11; November 2016; Page No. 04-05] https://www.researchgate.net/publication/312450798_Potential_use_of_ethnoveterinary_medicine_for_retained_placenta_in_cattle_in_Mogonono_Botswana
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Technology Transfer Terms
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Licensing / Technical Support / Consultancy / Turn Key Project
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